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Medical Chemistry and Biochemistry

CYTOCHROME P-450: genetic and population aspects

CYTOCHROME P-450: genetic and population aspects

Need of carrying out a pharmacological genotyping for providing the individualized pharmacotherapy is shown in the monograph based on the analysis of own and literary data of the central link of drug pharmacokinetics– systems of cytochrome P-450, taking into account its genetic polymorphysm. The monograph is intended for the clinical pharmacologists, geneticists and experts dealing with this problem.

Mavlyanov I.R., Ashirmetov A.Kh., Mavlyanov Z.I., Jarilkasinova G.J.: CYTOCHROME P-450: genetic and population aspects, Pavol Jozef Šafárik University in Košice, Košice 2017, ISBN 978-80-8152-526-1.

 
author: Iskander Rahimovich Mavlyanov, Abdurashid Khamidovich Ashirmetov, Zafar Iskandarovich Mavlyanov, Gavhar Januzakovna Jarilkasinova | UPJŠ LF v Košiciach | discipline: Biology, Pharmacology, Medical Chemistry and Biochemistry | category: Educational works | keywords: cytochrome P-450 | attachment: 2 | viewed: 83x | published on: 5.12.2017 | last modified on: 23.3.2018

Protein preparation

Protein preparation

This course contains five sub-courses, which consist of theoretical and practical parts. The individual sub-courses should provide students simple and quick approaches needed for solving basic scientific problems that could rise during the course of their bachelor, diploma or PhD study. The first set will allow students to gain knowledge about protein cloning, expression and purification. The second part focuses on biochemical characterization of enzymes via their enzymatic activity as well as protein-protein interactions. The third set will provide simple biochemical methods to detect protein-protein and protein-DNA interactions as well as monitor motor activity of protein.

 
author: Lumír Krejčí | LF MU | discipline: Biophysics, Medical Chemistry and Biochemistry | category: Educational works | keywords: Protein-protein and protein-DNA interaction methods, EMSA, pull-down, yeast 2 hybrid, Helicase assay, sumoylation | attachment: 5 | viewed: 2877x | published on: 18.6.2012 | last modified on: 20.8.2013

Practical exercises from Medical Biochemistry for students of Dental Medicine

Practical exercises from Medical Biochemistry for students of Dental Medicine

The laboratory manuals are developed to the foreign students of medicine for practical laboratory exercise and verification of knowledge from medical biochemistry. Exercises are gathered into bigger groups by topics. Student can apply their manual skill in performing of the experiments, and also train their ability in evaluation of results and making of diagnoses.

First published: Tomečková V., Kron I., Mareková M.: Practical exercises from biochemistry, Univerzita Pavla Jozefa Šafárika v Košiciach, Košice 2011, ISBN 978-80-7097-874-0.

 
author: Peter Urban, Vladimíra Tomečková, Jana Mašlanková, Marek Stupák, Mária Mareková | UPJŠ LF v Košiciach | discipline: Medical Chemistry and Biochemistry | category: Educational works | keywords: biochemistry, practical exercises | attachment: 26 | viewed: 13734x | published on: 15.2.2011 | last modified on: 9.2.2018

Automatic urinalysis

Automatic urinalysis

An automated unit for chemical and microscopic examination of urine. This instruction video on automatic biochemical analysers was made in collaboration with the Dept. of Clinical Biochemistry and Haematology of the Faculty Hospital in Brno, the Dept. of Biochemistry, and the Data Processing Centre of the MU Fac. of Medicine in Brno. It is provided with a spoken commentary which, on the one hand, gives a static description of the individual components of the analyser and, on the other, accompanies individual demonstrations of its function. The video also contains a description and a demonstration of the functioning of the automated urine laboratory (automated unit for chemical and microscopic examination of urine iQ200).

 
author: Milan Dastych, Jaroslav Winkler | LF MU | discipline: Medical Chemistry and Biochemistry | category: Digital video, Presentations | keywords: Automation, Clinical biochemistry, iQ200, Automated unit, Urine laboratory | attachment: 1 | viewed: 5650x | published on: 27.3.2009 | last modified on: 27.10.2011

Introduction to Biological Psychiatry

Introduction to Biological Psychiatry

Biological psychiatry occupies itself by mental disorders from biological, chemical and physical point of view. It is postulated that changes in brain signal transmission are essential in development of mental disorders. The purpose of this teaching material is to describe cellular and molecular properties of neurons, mechanisms of psychotropic drugs action and biological basis of mental disorders. Familiarity with biochemistry and physiology is supposed.

 
 

Essentials of Medical Chemistry and Biochemistry

Essentials of Medical Chemistry and Biochemistry

The English text has been created for one-semester course of medical chemistry. It is assigned for the students of English program of General medicine and Dentistry studies. The textbook summarizes essential facts from chemistry and biochemistry. The selection of topics emphasizes the biochemical processes and the metabolic conversions of compounds occurring in the human body. The knowledge of presented facts is necessary for understanding metabolic processes on cellular and organ level in the following studies of biochemistry

 
author: Jiří Dostál, Hana Paulová, Eva Táborská, Josef Tomandl | LF MU | discipline: Medical Chemistry and Biochemistry | category: Educational works, Educational websites | keywords: medical chemistry, biochemistry, biomolecules | attachment: 1 | viewed: 3342x | published on: 26.5.2014 | last modified on: 24.7.2014

Molecular biology

Molecular biology

The terms "recombinant DNA technology", "DNA cloning", "molecular cloning", and "gene cloning" all refer to the same process: a transfer of a DNA fragment of interest from one organism to a self-replicating genetic element such as a bacterial plasmid. The DNA of interest can then be replicated (together with the rest of the plasmid) in a foreign host cell. This technology is a common practice in molecular biology labs today.

 
author: Lumír Krejčí | LF MU | discipline: Biophysics, Medical Chemistry and Biochemistry | category: Educational works | keywords: Molecular biology, mutagenesis, PCR, DNA, cloning, DNA ligation, transformation, plasmid preparation, protein purification, chromatography, sumoylation, SDS-PAGE | attachment: 2 | viewed: 2999x | published on: 18.6.2012 | last modified on: 20.8.2013

Random access analyser (HITACHI 917)

Random access analyser (HITACHI 917)

The automatic biochemical analyser Hitachi 917 is a prototype of high-capacity selective analyser. It has a capacity of 800 photometric tests per hour and the possibility of selective choice out of a range of fifty biochemical tests. This involves spectrophotometric methods that utilise measurements of absorbance of the reaction mixture in a cuvette at various wavelengths. A part of the analyser is an ion-selective electrode module for the determination of sodium, potassium, and chlorides. The duration of the video is 17 min.

 
author: Milan Dastych, Jaroslav Winkler | LF MU | discipline: Medical Chemistry and Biochemistry, Pathology and Forensic Medicine | category: Digital video, Presentations | keywords: Automation, Clinical biochemistry, Analyser, HITACHI 917 | attachment: 1 | viewed: 7297x | published on: 27.3.2009 | last modified on: 27.10.2011

Blood taking

Blood taking

This video recording is destined for supplementation of the instruction in Clinical Biochemistry in biomedical disciplines and deals with the description of procedures used in the taking and processing of blood. It gives a concise documentation on the preparation of the patient prior to the taking and the procedure during the taking of venous blood. Emphasis is laid on the use of the closed system of blood taking. Mention is made of the transport and storage of samples, procedures of the taking of plasma and serum, and of obtaining and processing capillary blood.

 
author: Eva Táborská, Hana Bochořáková, Hana Paulová, Josef Tomandl, Jaroslav Winkler | LF MU | discipline: Medical Chemistry and Biochemistry | category: Multimedia, Digital video | keywords: blood taking, blood | attachment: 1 | viewed: 5243x | published on: 2.4.2008 | last modified on: 27.10.2011
 
SCHWARZ Daniel, DUŠEK Ladislav. A uniform platform for electronic publishing and sharing the educational content in the network of medical faculties MEFANET [online]. Masaryk University, [2008], [cited 2018-04-21]. Available from WWW: <http://portal.mefanet.cz>. Version 1.9 [2014].