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Psychopharmacs - antipsychotics

pps Psychopharmacs - antipsychotics
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Dept. of Psychiatry, Masaryk University , Brno slide slide-master-content slide-content Psychopharmacs : antipsychotics definition and history classification according to chemistry classification according to clinical efficacy mechanism of action pharmacokinetic doses and duration of treatment side effects indication literature slide slide-master-content slide-content Definition, history Neuroleptics ( antipsychotics, AP ) are psychopharmacs influencing psychic integration in a positive way Antipsychotics are the cornerstone of treatment of schizophrenia ... relapses with APs signif. lower than with placebo (circa 20% vs 50%) poor adherence leads to relapse and high costs to individuals, families, carers and society stopping medication is the most powerful predictor of relapse slide slide-master-content slide-content Mechanism of action all available clinically effective APs block D (dopamine) receptors, the potency to reduce psychotic symptoms is most closely correlated with the affinity to D2 receptor others systems may play important role (glutamate, noradrenaline, serotonin, GABA, neuropeptides) atypical APs differentially affect other systems (serotonin) - more specific pharmacological action generally safer, better tolerated APs differ in their ability to block the various receptors - e.g. in their side effects profiles, but no in their therapeutic profiles slide slide-master-content slide-content Mechanisms of action All the known APs share the common property of blocking DA receptor: blockade of DA receptors in the nigrostriatal DA pathway - a drug-induced parkinsonism blockade of DA receptors in the mesolimbic DA pathway - antipsychotic efficacy (especially positive symptoms) blockade of DA receptors in the mesocortical DA pathway - blunting of emotions and cognitive side effects blockade of DA receptor in tuberoinfundibular DA pathway - elevation of prolactin levels slide slide-master-content slide-content Mechanism of action - dopaminergic pathways of the CNS Stahl SM.: Essential Psychopharmacology, 2000 slide slide-master-content slide-content Pharmacokinetics most APs have high binding to plasma protein, volume of distribution, and lipid solubility the most important clinical generalisation is that all the APs can be given in a one daily dose once patient is in a stable condition APs are metabolised in the liver and reach steady plasma levels in 5-10 days ...

LF MU | discipline: Psychiatry, Psychology, Sexology | ...: Array | published on: 12. 1. 2006

11. week ST

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Gastric acid (pH 1.5 - 3.5) plays a key role in protein digestion by activating pepsinogen to pepsin, in addition to its antimicrobial function ... After a 12-hour fast, a nasogastric tube is inserted into the patient's stomach to empty the stomach contents. 2 ...

UPJŠ LF v Košiciach | discipline: Medical Chemistry and Biochemistry | ...: Array | published on: 16. 9. 2013

Anatomical dissection - abdomen and pelvis (videos)

Anatomical dissection - abdomen and pelvis (videos)

Licencia DAP-01 Layers of the abdominal wall 9.9.2022 MEFANET user DAP-02 Round ligament of liver (lig. teres hepatis) 9.9.2022 MEFANET user DAP-03 Lesser omentum (omentum minus) 9.9.2022 MEFANET user DAP-04 Celiac trunk and extrahepatal biliary ducts 9.9.2022 MEFANET user DAP-05 Liver in situ 9.9.2022 MEFANET user DAP-06 Liver (specimen) 9.9.2022 MEFANET user DAP-07 Oral cavity (specimen) 9.9.2022 MEFANET user DAP-08 Tongue 9.9.2022 MEFANET user DAP-09 Constrictor muscles of pharynx 9.9.2022 MEFANET user DAP-10 Stomach, duodenum, jejunum (specimens) 9.9.2022 MEFANET user DAP-11 Ileocecal orifice, vermiform appendix (specimen) 9.9.2022 MEFANET user DAP-12 Superior mesenteric artery, inferior mesenteric artery, typical features of intestines 9.9.2022 MEFANET user DAP-13 Abdominal wall from inside (umbilical folds, inguinal fossae) 9.9.2022 MEFANET user DAP-14 Large vessels in retroperitoneal space (aorta, inferior vena cava) 9.9.2022 MEFANET user DAP-15 Superficial inguinal ring in male 9.9.2022 MEFANET user DAP-16 Inguinal canal in female 9.9.2022 MEFANET user DAP-17 Inguinal canal in male 9.9.2022 MEFANET user DAP-18 Content of spermatic cord 9.9.2022 MEFANET user DAP-19 Testes (coverings) 9.9.2022 MEFANET user DAP-20 Kidney, renal hilum, fibrous capsule 9.9.2022 MEFANET user DAP-21 Urinary bladder, prostate 9.9.2022 MEFANET user DAP-22 Vessels and nerves on dorsum penis 9.9.2022 MEFANET user DAP-23 Penis, external morphology, sagittal and transverse section 9.9.2022 MEFANET user DAP-24 Fundiform and suspensory ligament of penis 9.9.2022 MEFANET user DAP-25 Male urogenital organs 9.9.2022 MEFANET user DAP-26 Testis (specimens) 9.9.2022 MEFANET user DAP-27 Female urogenital organs, sagittal section 9.9.2022 MEFANET user DAP-28 Female genital organs, specimens 9.9.2022 MEFANET user DAP-29 Uterus 9.9.2022 MEFANET user DAP-30 Female genital organs in situ 9.9.2022 MEFANET user DAP-31 Common and external iliac arteries, surrounding structures 9.9.2022 MEFANET user DAP-32 Nerves of lumbar plexus in retroperitoneum 9.9.2022 MEFANET user DAP-33 Pelvic floor muscles 9.9.2022 MEFANET user DAP-34 Ischioanal fossa, pudendal canal, urogenital diaphragm 9.9.2022 MEFANET user DAP-35 Sacral plexus, piriformis, coccygeus, levator ani, corona mortis 9.9.2022 MEFANET user DAP-36 Pudendal nerve in infrapiriform foramen and in pudendal canal 9.9.2022 MEFANET user Anatomy 1 [UA/A-GM1/14] Anatomy 2 [UA/A-GM2/14] Anatomy 3 [UA/A-GM3/14] Department of Anatomy, Department of Medical Informatics and Simulator Medicine Anatomical dissection - upper limb (videos) Anatomical dissection - lower limb (videos) Anatomical dissection - thorax, axilla, respiratory system (videos) Anatomical dissection - head and neck (videos) Selected animations from Anatomy ...

UPJŠ LF v Košiciach | discipline: Anatomy | keywords: dissection, cadaver, vessels, nerves, muscles, bones, abdomen, pelvis | published on: 8. 2. 2020

Exocrine Pancreatic Function Test 13C-Mixed Triglyceride Breath Test

pdf Exocrine Pancreatic Function Test 13C-Mixed Triglyceride Breath Test
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... page 0 5 10 15 20 25 30 35 40 45 NON CHP-A CHP-B CHP-C1/2 CHP-C3 0 5 10 15 20 25 30 35 40 45 NON CHP-A CHP-B CHP-C1/2 CHP-C3 1212 EXOCRINE PANCREATIC FUNCTION TESTS Kocna P ... Cut-off value of cPDR 13C-MTG test calculated by mathematical approximation, and from the control group of 62 NON-CHP subjects is equivalent - 30% 13C-MTG test value, in CHP-A/B, classified as clinicaly normal function, was normal/high in 60 from 64 (94%), while FELA was normal/high only in 45 (70%) Agreement of FELA and 13C-MTG in NON-CHP was 90.2%, as well as in CHP-A/C1/C2 (without complications) - 89.5% Discrepancy of FELA and 13C-MTG in 40.4% was found in groups CHP-B/C3 with complications ...

1.LF UK | discipline: Gastroenterology and Hepatology | ...: Array | published on: 19. 2. 2007

Dementia

pps Dementia
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... perseveration (following a topic after its change), palilalia (repetition of the last word), logoclonia (repetition the last syllabe), logorhea (meaningless outpouring of words), echolalia (repetition of other's speech) visuospatial abilities (reproduction of a complex drawing...) ... slide slide-master-content slide-content DSM IV Diagnostic criteria A: development of multiple cognitive deficits memory impairment aphasia, apraxia, agnosia, impaired executive functions B: significant impairment in social or occupational functioning C: gradual onset with continuing cognitive decline D: cognitive deficits are not due other CNS condition systemic condition substance induced conditions E: deficits do not occure exclusively during a delirium slide slide-master-content slide-content Scales MMSE (MiniMental Scale Examination) screening; orientation, attention, registration, recall, language, manipulating information, praxis 0-30; < 24 = cognitive dysfunction; loss of 3 points a year is obvious in AD slide slide-master-content slide-content Pathogenesis I: Senile plaques insoluble deposits of amyloid β-peptide (Aβ) fragment of the amyloid precursor protein (APP, membrane protein – function?) ...

LF MU | discipline: Psychiatry, Psychology, Sexology | ...: Array | published on: 12. 1. 2006

International Research Interdisciplinary School IRIS

International Research Interdisciplinary School IRIS

It is a very intensive and dynamic 6 - day course, full of discussions, presentations, soft skills, critical thinking, teamwork and feedback. It is focused on creating a clinical trial and scientific report.   COURSE CONTENT Research Study Protocol Study Population and Outcomes (Study Outcome) Data collection and analysis (Study design, Baseline variables, Data collection,...) ...

LF UK v Bratislave | discipline: Other | keywords: IRIS, school, research | published on: 30. 6. 2020

Practical lessons 7

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Spinal nerves contain both sensory and motor fibres that emerge from the spinal cord as a separate roots and unite to form mixed nerve ... v=x0w_VDQ0Tv4 page The nervous system is a vast network that can be divided according to two criteria: 1 ...

UPJŠ LF v Košiciach | discipline: Anatomy | ...: Array | published on: 30. 6. 2018

11. week WT

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Principle Triacylglycerols, fatty acids, phospholipids, and cholesterol, after hydrolysis with sulphuric acid, react with a phosphovanillin reagent forming a red-coloured product ... Heat the test tubes in a boiling water bath for 15 min to perform hydrolysis ...

UPJŠ LF v Košiciach | discipline: Medical Chemistry and Biochemistry | ...: Array | published on: 16. 9. 2013

Procedures of Assisted Reproduction

Procedures of Assisted Reproduction

The basic principle of IVF is retrieval of an oocyte and its fertilisation by a spermatozoon in laboratory environment. The fertilised oocytes are stored in a cultivation box where their further development proceeds ...

LF MU | discipline: Obstetrics, Gynaecology | keywords: infertility, IVF, assisted reproduction, embryology, andrology | published on: 19. 4. 2010

VI - Lymphocytes

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• Evaluation of function -lymphocyte proliferation tests - determines response to various stimuli: – specific (antigen, anti CD-3) – non-specific -polyclonal mitogens: PHA (Phytohaemagglutinin), ConA (Concanavaline A), PWM (Pokeweed mitogen) page Delayed-type of hypersenzitivity test page Tuberculin test page page page Cell-Mediated Immunity (CMI) tests • Uses the principle of delayed type of hypersensitivity • Common anamnestic antigens are used (tuberculin, candidin, trichofitin, staphylococcal antigens…) • In normal situation induration shout be formed by 48 hours ... • If the patient does nor react to majority of antigens a deficiency of T- cell mediated immunity is suspected ...

LF MU | discipline: Immunology, Allergology | ...: Array | published on: 6. 9. 2013

Research Activities in Dentistry

Research Activities in Dentistry

The teaching material is a collection of lectures divided into five sections: Introduction, Basics of methodology in scientific work, Evidence levels in dentistry, Clinical trial methodology (not) only for dentists, Questionnaires and psychometrics, Introduction to biostatistics, Genetic association studies and oral microbiome, Lipoxins and resolvins in the treatment of periodontitis, Use of nanofibres for application of bioactive substances in the prevention of oral diseases, Obstructive sleep apnea (not only) in children from the perspective of a dentist & orthodontist, Congenital developmental anomalies of the orofacial region (cleft defects), Research and development of modern oral pharmaceutical forms, Mucoadhesive films designed to cover defects of the oral mucosa, Head and neck cancer – clinical studies, therapy, microbiome, 3D virtual planning and reconstruction of the lower jaw, Modern methods in studying the development and maintenance of the vitality of the tooth, Odontogenesis – use of alternative model organisms, Translational research in life sciences: challenges and possibilities ...

LF MU | discipline: Dentistry | keywords: dentistry, basic research, applied research, genetics, oral pathology, microbiome, odontogenesis, animal model, therapy | published on: 27. 1. 2021

Paediatric propedeutics in paediatric cardiology

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... date 2020-10-29T14:03:47Z pdf:PDFVersion 1.3 stream_content_type application/pdf pdf:hasXFA false access_permission:modify_annotations true access_permission:can_print_degraded true dcterms:created 2020-10-29T14:03:47Z Last-Modified 2020-10-29T14:03:47Z dcterms:modified 2020-10-29T14:03:47Z dc:format application/pdf; version=1.3 Last-Save-Date 2020-10-29T14:03:47Z access_permission:fill_in_form true pdf:docinfo:modified 2020-10-29T14:03:47Z stream_name https://portal.med.muni.cz/_download12345/5/jicinska/paediatric-cardiology-jicinska-a.pdf meta:save-date 2020-10-29T14:03:47Z pdf:encrypted false modified 2020-10-29T14:03:47Z pdf:hasMarkedContent false Content-Type application/pdf stream_size 3462004 X-Parsed-By org.apache.tika.parser.DefaultParser X-Parsed-By org.apache.tika.parser.pdf.PDFParser meta:creation-date 2020-10-29T14:03:47Z stream_source_info url created 2020-10-29T14:03:47Z access_permission:extract_for_accessibility true access_permission:assemble_document true xmpTPg:NPages 21 Creation-Date 2020-10-29T14:03:47Z pdf:hasXMP false access_permission:extract_content true access_permission:can_print true producer macOS Verze 10.15.7 (sestava 19H2) Quartz PDFContext access_permission:can_modify true pdf:docinfo:producer macOS Verze 10.15.7 (sestava 19H2) Quartz PDFContext pdf:docinfo:created 2020-10-29T14:03:47Z page Study notes for lectures in paediatric cardiology not only for paediatricians: A) Paediatric propedeutics in paediatric cardiology B) How to make a diagnosis in paediatric cardiology C) Paediatric cardiology I D) Paediatric cardiology II Hana Jičínská Medical faculty of Masaryk University Brno Department of Paediatrics, University Hospital Brno page Notes for lectures in paediatric cardiology not only for paediatricians: A) PAEDIATRIC PROPEDEUTICS in Paediatric Cardiology Hana Jičínská Medical faculty of Masaryk University Brno, Department of Paediatrics, University Hospital Brno page The evaluation of the child with suspicion on cardiac disease page FAMILY HISTORY Family history: Parents, siblings, grandparents, next closed relatives - congenital defects: cardiac, non-cardiac - disease with genetic background (syndrome) - further cardiovascular disease: cardiomyopathies, inflammatory heart disease, hypertension - arrhythmias Initial signs of disease, duration of disease, death in family page Past history Birth history: Prenatal - previous repeated abortions in the mother, pregnancy in the mother - Risk factors in the mother, contact with teratogens, medication in pregnancy - Disease of the mother - 1st and 2nd trimester‘s screening results page History Neonatal: Childbirth: - In term? ... Anatomy of the Human Body page Heart murmur Intensity Assessed using Lewin‘s scale from 1 to 6 in 4-6 thrill present page Heart murmur proto- meso- tele- systolic diastolic Duration of murmur Daniel Chang revised original work of DestinyQx page Heart murmur in children Pathologic murmurs - In congenital or heart defects - In some very severe CHD there is no murmur Innocent murmurs: - Heard only in precordium without propagation, they change with the change of position of the body - low intensity (1-2) - 2nd to 4th left intercostal spaces between the left sternal border and the apex page Family History Physical examination are important in the process of making a diagnosis in the patient with cardiac disease ...

LF MU | discipline: Cardiology, Angiology | ...: Array | published on: 23. 10. 2020

Spinal cord compress

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Orthotics page operated patients: 727 metastases 386 benign 98 malign 175 tumour-like affections 68 1984 – 2005 page mammar cancer 75 Grawitz. tumour 54 The most frequent metastases: Malignant tumours: myeloma 72 chordoma 17 chondrosarcoma 12 page anterior 168 posterior 350 combined – 1 team 164 - 2 teams 45 Surgeries page Frankel scale (now ASIA scale): A plegia, anesthesia B plegia, some sensory function C usefulles motor function D useful motor (gait) E normal page During surgery – heart failure, extensive blood loss Chylothorax Infection Exitus Complications page Quick progression of paresis Surgery to 24 hours after plegia onset Conclusion page SPINE INJURIES page AO classification of T+L injuries A anterior column injury (wedge, split, burst) B both columns – flexion distraction C both columns with rotation page Neural deficit in Th + L spine  A type – mainly burst fractures  B type - seldom  C type – majority of patients page A3.2.1 A3.3.3 A1.3 A3.1.1 A3 burst page Injuries with neural deficit  Transport to spine surgery department  X-rays, CT, (MRI), int., neurol ... both columns C 3-7 INJURIES AO classification 1.Bone injury 2.Bone-ligamentous 3.Ligamentous page A1 type fracture - bone injury wedge Neural deficit: burst fractures - majority of cases page Combined C5-6 surgery C type - dislocation page Neural deficit in C spine A type – burst (C5-7) – majority of cases B type – posterior column – seldom C type – both columns – majority of cases Surgery Anterior – decompression, anterior fusion and plates – majority of cases Combined surgery – C type injuries ...

LF MU | discipline: Surgery, Traumatology and Orthopaedics | ...: Array | published on: 13. 5. 2016

Osteoarthritis

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Rozkydal page Synovial joint The end of bones Hyaline cartilage Ligaments Joint capsule Synovial membrane Synovial fluid page Hyaline cartilage Chondrocytes Matrix – intercelullar mass: Fibrilar structure - collagen Proteoglycans Proteins of noncollagen nature Hyaluronic acid Water – 70 volume percent page Hyaline cartilage Chondrocytes- 2 percent of volume Localised in lacunes of matrix Isogenetic groups 2-8 cells from one mother cell page Hyaline cartilage - layers Superficial Middle Deep Zone of calcifying Catilage Bone page Collagen Collagen type II (3 alfa-1 chains- 90 %) Chains form fibrils Fibrils form a three dimensional network Paraler to the surface In deep layers in columns page Proteoglycans- PG They are high hydrophylic - elasticity !! ... Synthetic activity of chondrocytes is lower The amount of chondrocytes and PG is lower page Recommended treatment Paracetamol- up to 4 g per day NSA - + inhibitors of proton pump (omeprazol) Chondroprotectives Hyaluronic acid Local corticosteroids Pain department- in a case we can not do surgery a nelze page PRP- platelets rich plasma ACP- autologous conditioned serum- Orthokine Mesenchymal stem cells ? ...

LF MU | discipline: Surgery, Traumatology and Orthopaedics | ...: Array | published on: 15. 4. 2009

Hardware

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� there were several architectures developed during the computers history, � the significant influence had Von Neumann architecture, � basic architecture for a long time.� basic architecture for a long time ... � formatting: � FAT, FAT 32, NTFS, HPFS, ext2fs page � FDD – Floppy Disc Drive: � to read/write data from/on floppy discs, � used also to boot computer: 5¼” – 360kB, 720kB a 1,2MB, HARDWAREHARDWARE –– Main parts of PCMain parts of PC � 5¼” – 360kB, 720kB a 1,2MB, � 3½” – 1,44MB ...

UPJŠ LF v Košiciach | discipline: Medical Informatics and Information Science | ...: Array | published on: 25. 4. 2008

Hypertext atlas of Fetal Pathology

Hypertext atlas of Fetal Pathology

Hypertext atlas of fetal and neonatal pathology is a free resource for pregraduate students of medicine, pathologists and other health professionals dealing with prenatal medicine ... The atlas is suitable both for medical students and pathologists as a teaching and reference tool. The atlas is going to be further expanded while keeping the high quality of the images ...

LF MU | discipline: Anatomy | keywords: neonatology, foetopathology, foetus, neonatal, foetal, newborn, pregnancy | published on: 17. 4. 2008

IX - Immune response to infections

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... date 2013-10-09T12:30:42Z pdf:PDFVersion 1.5 pdf:docinfo:title Snímek 1 xmp:CreatorTool Microsoft® PowerPoint® 2013 stream_content_type application/pdf pdf:hasXFA false access_permission:modify_annotations true access_permission:can_print_degraded true dc:creator fnusa language cs-CZ dcterms:created 2013-10-09T12:30:42Z Last-Modified 2013-10-09T12:30:42Z dcterms:modified 2013-10-09T12:30:42Z dc:format application/pdf; version=1.5 Last-Save-Date 2013-10-09T12:30:42Z pdf:docinfo:creator_tool Microsoft® PowerPoint® 2013 access_permission:fill_in_form true pdf:docinfo:modified 2013-10-09T12:30:42Z stream_name https://portal.med.muni.cz/_download12345/7/immunology-general-medicine/immune-response-to-infections.pdf meta:save-date 2013-10-09T12:30:42Z pdf:encrypted false dc:title Snímek 1 modified 2013-10-09T12:30:42Z pdf:hasMarkedContent true Content-Type application/pdf stream_size 530212 pdf:docinfo:creator fnusa X-Parsed-By org.apache.tika.parser.DefaultParser X-Parsed-By org.apache.tika.parser.pdf.PDFParser creator fnusa dc:language cs-CZ meta:author fnusa meta:creation-date 2013-10-09T12:30:42Z stream_source_info url created 2013-10-09T12:30:42Z access_permission:extract_for_accessibility true access_permission:assemble_document true xmpTPg:NPages 15 Creation-Date 2013-10-09T12:30:42Z pdf:hasXMP false access_permission:extract_content true access_permission:can_print true Author fnusa producer Microsoft® PowerPoint® 2013 access_permission:can_modify true pdf:docinfo:producer Microsoft® PowerPoint® 2013 pdf:docinfo:created 2013-10-09T12:30:42Z Snímek 1 page Immune response to infections page Factors influencing the extent and severity of infection • Pathogen factors – Dose – Virulence of organism – Route of entry • Host factors – Integrity of non-specific defences – Competence of the immune system – Genetic influences – Previous exposure to antigen – Existence of co-infection page Immune response to viral infections – Non-speciphic immunity • Interferons ( a and b) • Natural killer cells (NK buňky) • Receptor-like molecules in various secretions • In some situations also: – Activation of the complement system (EBV) – Phagocytosis – Speciphic immunity • Antibodies – neutralization of extracellular viruses • Tc lymphocytes – elimination of virus-infected cells page Mechanisms of antiviral immunity page The action of interferon (IFN) page Natural killers (NK cells) • Originate in non-T non-B lymphocyte lineage ... page page Viral strategies to evade the immune response • Antigenic variations – antigenic drift - minor changes – antigenic shift - major changes • Long-term survival in a host – Viral persistence – Viral latency – Oncogenic transformation • Immunosuppressive effect of viruses page Immunosuppressive effects of viruses • Suppression of T-cells : HIV, morbilli, CMV, • Inhibition of MHC antigens expression: CVM (binds b-2 microglobulin), Adenoviruses, RSV - decreases expression of HLA antigens • Production of inhibitory cytokies: EBV ( IL- 10 - like factor) page Damage of a host caused by anti-viral immune response • Autoimmune diseases: hemolytic anemia after EBV infection, autoimmune hepatitis induced by hepatitis-B virus • Immune complex diseases: arthritis in hepatitis B, vasculitis • Tc - meadited diseases: rash in exanthematic viral diseases, myocarditis caused by coxackie virus page Immune responses to bacterial infections • Non-specific immunity – Mechanical barriers – Phagocytosis – Complement system • Specific immunity – Antibodies - opsonisation, complement- activation, neutralisation of toxins, binding to receptors – T-lymphocytes - against intracellular parasites page Bacterial evasions of immune defences • Antiphagocytic machanisms: toxins, capsular polysaccharides • Inhibition of the complement system: Str ...

LF MU | discipline: Immunology, Allergology | ...: Array | published on: 6. 9. 2013

Grouping data

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... page RELATIVE FREQUENCY TABLE • relative frequency is proportion of values falling within a particular class • frequency divided by the total number of values • the sum of relative frequency is 1 page CUMULATIVE RELATIVE FREQUENCY TABLE • cumulative relative frequency is the accumulation of the previous relative frequencies • the sum of the relative frequencies for all values that are less than or equal to the given value • the last entry of cumulative relative frequency column is 1 (100% of data) page HISTOGRAM • distribution of total frequency into different classes/group • can display large data sets • consists of continuous bars (boxes) • vertical axis is labeled as frequency (relative frequency) • frequency curve smoothly connects the mid-points of all bars page • line chart • we can also get a polygon from the histogram by connecting the polyline with the center of the top of all its columns HISTOGRAM page NUMBER OF CLASSES AND CLASS INTERVAL WIDTH Range (max - min) has to be divided into 𝒌 classes • 𝒌 is usually between 5 and 15, (can be 𝒌 ≅ 𝒏) • avoid too few or to many classes in distribution – optimal value depends on data to be processed (researcher’s knowledge) Sturges’s formula • can be used to determine number of classes and range of class intervals (width) Number of classes: 𝒌 = 𝟏 + 𝟑. 𝟑𝟐𝟐 log𝟏𝟎 𝒏 where 𝒏 is the number of values. Class interval width: 𝒄 = 𝑹𝒂𝒏𝒈𝒆 𝒌 • rounded to a whole number The classes should be evenly distributed ...

UPJŠ LF v Košiciach | discipline: Medical Informatics and Information Science | ...: Array | published on: 11. 12. 2009

Outpatient clinic - Create outpatient clinic card

ppsx Outpatient clinic - Create outpatient clinic card
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... embedded slide3_rId3 embedded slide3_rId4 SK: Filter ambulantných kariet ENG: Filter of outpatient cards Filter to select group of patients/their cards: Všetci – all patients V čakárni – in the waiting room Aktívne – active cards Archívne – archived cards Diár – diary (ambulatory monitored patients) V dispenzári – dispensatory patients embedded slide3_rId5 SK: Založenie karty ENG: Create new outpatient card To create a new card for ambulatory treated patient. There can be only one outpatient clinic card created in particular outpatient clinic ... SK: Pridať ENG: Add Confirm it, if your patient is not in the Central register. There will be a need to fill in identification data as it will be a new patient ...

UPJŠ LF v Košiciach | discipline: Medical Informatics and Information Science | ...: Array | published on: 18. 3. 2011

Heart and Chest Imaging

ppt Heart and Chest Imaging
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... cp:revision 56 date 2006-05-14T19:55:21Z Company FN HK stream_content_type application/vnd.ms-powerpoint meta:word-count 1500 dc:creator novotjos extended-properties:Company FN HK Word-Count 1500 dcterms:created 2002-04-28T13:49:40Z dcterms:modified 2006-05-14T19:55:21Z Last-Modified 2006-05-14T19:55:21Z Last-Save-Date 2006-05-14T19:55:21Z stream_name https://mefanet.lfhk.cuni.cz/_skryty_repositar45465-gfgf454/19/12-cardiacchest-praktikum-ppt_4a19c7dd2cc4a.ppt meta:save-date 2006-05-14T19:55:21Z dc:title Thoracic radiology Application-Name Microsoft PowerPoint modified 2006-05-14T19:55:21Z Edit-Time 808136980000 Content-Type application/vnd.ms-powerpoint Slide-Count 98 stream_size 30454272 X-Parsed-By org.apache.tika.parser.DefaultParser X-Parsed-By org.apache.tika.parser.microsoft.OfficeParser creator novotjos meta:author novotjos extended-properties:Application Microsoft PowerPoint meta:creation-date 2002-04-28T13:49:40Z stream_source_info url meta:last-author Administrator meta:slide-count 98 Creation-Date 2002-04-28T13:49:40Z xmpTPg:NPages 98 Last-Author Administrator Revision-Number 56 Author novotjos Thoracic radiology slideShow slide slide-master-content slide-content Chest radiology Department of Radiology University Hospital Hradec Kralove slide slide-master-content slide-content Outline Imaging methods Normal chest X – ray Abnormal imaging patterns : CXR, other methods slide slide-master-content slide-content Imaging methods - chest CXR posteroanterior upright anteroposterior supine lateral films conventional tomography, fluoroscopy CT: computed tomography conventional and spiral CT non-contrast and contrast-enhanced study CT angiography – pulmonary embolism HRCT – high resolution CT Ultrasonography MR Angiography Scintigraphy, PET slide slide-master-content slide-content CXR – PA and lateral view slide slide-master-content slide-content technical points quality of exposure visibility of vascular pattern and spinal column symmetry spinous processes, medial ends of clavicles inspiration level of diaphragm (ant. 6r, post. 9r) bones, chest wall (breasts, nipples) free diaphragmatic angles size and contours of mediastinum C-T ratio < 0.5 hila A-B index < 1.2 narrower upper vessels symmetry of lung transparency, regularly branching vascular pattern, missing in peripheral 15 mm bands PA view – normal pattern slide slide-master-content slide-content technical points quality of exposure visibility of vascular pattern and spinal column symmetry spinous processes, medial ends of clavicles inspiration level of diaphragm (ant. 6r, post. 9r) bones, chest wall (breasts, nipples) free diaphragmatic angles contours and size of the mediastinum C-T ratio < 0.5 hila A-B index < 1.2 narrower upper vessels symmetry of lung transparency, regularly branching vascular pattern, missing in peripheral 15 mm bands PA view – normal pattern slide slide-master-content slide-content Normal heart, PA projection slide slide-master-content slide-content Normal CXR, lateral projection slide slide-master-content slide-content slide slide-master-content slide-content Mediastinum - compartments slide slide-master-content slide-content technical points quality of exposure visibility of vascular pattern and spinal column symmetry spinous processes, medial ends of clavicles inspiration level of diaphragm (ant. 6r, post. 9r) bones, chest wall (breasts, nipples) free diaphragmatic angles contours and size of the mediastinum C-T ratio < 0.5 hila A-B index < 1.2 narrower upper vessels symmetry of lung transparency, regularly branching vascular pattern, missing in peripheral 15 mm bands PA view – normal pattern slide slide-master-content slide-content technical points quality of exposure visibility of vascular pattern and spinal column symmetry spinous processes, medial ends of clavicles inspiration level of diaphragm (ant. 6r, post. 9r) bones, chest wall (breasts, nipples) free diaphragmatic angles contours and size of the mediastinum C-T ratio < 0.5 hila A-B ratio < 1.2 symmetry of lung transparency, regularly branching vascular pattern, missing in peripheral 15 mm bands PA view – normal pattern slide slide-master-content slide-content Arterio-bronchial ratio B P slide slide-master-content slide-content Arterio-bronchial ratio conventional tomography slide slide-master-content slide-content technical points quality of exposure visibility of vascular pattern and spinal column symmetry spinous processes, medial ends of clavicles inspiration level of diaphragm (ant. 6r, post. 9r) bones, chest wall (breasts, nipples) free diaphragmatic angles contours and size of the mediastinum C-T ratio < 0.5 hila A-B index < 1.2 narrower upper vessels reflects distribution of blood flow valid only on erect films symmetry of lung transparency, regularly branching vascular pattern, missing in peripheral 15 mm bands PA view – normal pattern slide slide-master-content slide-content 1/3 2/3 U M L 9 6 PA VIEW – lung fields slide slide-master-content slide-content Interlobar fissures slide slide-master-content slide-content                                                  slide slide-master-content slide-content Right lung slide slide-master-content slide-content Left lung slide slide-master-content slide-content U M L PA VIEW – lung fields slide slide-master-content slide-content ICU films -AP projection - sitting - supine position limited diagnostic value lung aeration, PNO, gross abnormalities monitoring devices, lines widened mediastinal shadow C-T ratio < 0.6 equal size of upper and lower hilar vessels slide slide-master-content slide-content Supine x upright films S U slide slide-master-content slide-content Vertical versus horizontal beam direction slide slide-master-content slide-content Ultrasonography cannot pass through the aerated lung quickest and the most efficient method for depiction of pleural fluid guidance of interventional procedures slide slide-master-content slide-content Chest CT method of choice for further work-up of patient with chest disease morfological diagnosis mediastinum, lung parenchyma, vessels guidance for interventional procedures (lung biopsies, drainages) slide slide-master-content slide-content Conventional x spiral CT incremental scanning spiral (helical) scanning slide slide-master-content slide-content slide slide-master-content slide-content slide slide-master-content slide-content High resolution CT (HRCT) sequentional CT scanning thin scan collimation high spatial frequency algorithm the most valuable method for: interstitial parenchymal processes details of masses bronchi slide slide-master-content slide-content Pulmonary CT Angiography spiral CT technique contrast enhancement dg. pulmonary embolism the method of choice for diagnosis of PE in patients with chronic cardiopulmonary disease slide slide-master-content slide-content slide slide-master-content slide-content Pulmonary angiography gold standard for diagnosis of pumonary embolism currently rarely used replaced by ventilation/perfusion scintigraphy spiral CT angiography slide slide-master-content slide-content Imaging methods - heart CXR PA upright, AP supine, lateral films conventional tomography, fluoroscopy Ultrasonography transparietal, transoesophageal CT: computed tomography CT angiography – pulmonary embolism, aorta, pericardium, tumors multislice CT – coronary arteries MR – morphology, functional studies, myocardial viability Coronarography, cardioangiography Scintigraphy, PET slide slide-master-content slide-content Pulmonary vessels – MR angiography slide slide-master-content slide-content Cardiac MR - cine mode slide slide-master-content slide-content Fetal echocardiography method of choice for fetal heart evaluation no other possibility in fetus high accuracy in experienced hands slide slide-master-content slide-content Fetal echocardiography slide slide-master-content slide-content Angiocardiography slide slide-master-content slide-content Coronarography slide slide-master-content slide-content Multislice CTA coronary arteries slide slide-master-content slide-content Abnormal patterns - heart slide slide-master-content slide-content Mitral heart shape - triangle triangular shape left atrial enlargement „Kernschatten“ double right contoure dorsal extension postcapillary hypertension redistribution to upper LF interstitial edema alveolar oedema natural history: precapillary hypertension slide slide-master-content slide-content Mitral stenosis Normal heart slide slide-master-content slide-content Mitral valve disease - stenosis slide slide-master-content slide-content Aortal heart shape – „duck“ left ventricular enlargement extension to the left sinking of the apex towards the diaphragm natural history: left heart failure left atrial enlargement „Kernschatten“ double right contoure dorsal extension postcapillary hypertension redistribution to upper LF interstitial edema alveolar oedema slide slide-master-content slide-content Aortic valve lesions slide slide-master-content slide-content I.- pulmonary venous hypertension: mitral stenosis, left ventricular failure slide slide-master-content slide-content Interstitial edema after treatment slide slide-master-content slide-content Alveolar edema slide slide-master-content slide-content Right ventricular enlargement retrosternal space filling prominence of pulmonary arch heart apex above the diaphragm slide slide-master-content slide-content Generalised heart enlargement ischemic heart disease myocardiopathy myocarditis pericardial fluid slide slide-master-content slide-content II. pulmonary arterial (precapillary) hypertension normal: A-B ratio < 1.2 pulmonary embolism „cor pulmonale“ Eisenmenger sy high altitude idiopathic slide slide-master-content slide-content III. pulmonary hyperemia – left to right shunting ASD, VSD, PDA arterial and venous dilatation slide slide-master-content slide-content VI. pulmonary oligemia – tetralogy of Fallot narrowing of both arteries and veins pulmonary stenosis, TOF, hypocirculatory status slide slide-master-content slide-content Pericarditis exudativa slide slide-master-content slide-content Pericarditis calcarea slide slide-master-content slide-content Abnormal patterns - lungs slide slide-master-content slide-content SHADOWS (compartments): ALVEOLAR PATTERN: CONSOLIDATION, EDEMA, COLLAPSE (ATELECTASIS) INTERSTITIAL PATTERN LUNG NODULE (S), MASSES PLEURAL EFFUSION, MASSES, CHEST WALL MEDIASINAL MASSES LUCENCIES: EMPHYSEMA CAVITY PNEUMOTHORAX POST MASTECTOMY slide slide-master-content slide-content Lung parenchyma pulmonary acinus (primary lobule) apr. 7 mm, cca 400 alveoli, supplied by terminal bronchiole and arteriole secondary lobule last structure surrounded with connective tissue (septae) 15 – 20 mm, 3-5 acini, supplied with secondary bronchiole and arteriole slide slide-master-content slide-content Alveolar pattern - consolidation shadowing and air-bronchogram complete filling of lung segments, lobes etc ... compressive (pleural fluid, PNO) fibrous, adhesive (RDS), rounded (with pleural disease) slide slide-master-content slide-content Left lower lobe consolidation (with some collapse) elevation of left hemidiaphragm silhouette sign preservation of left heart border loss of diaphragmatic contour slide slide-master-content slide-content Silhouette sign - practise lingular consolidation - pneumonia slide slide-master-content slide-content Right lower lobe collapse There is a silhouette sign with the right paravertebral border but the right heart border is preserved ...

LF UK Hr. Králové | discipline: Cardiology, Angiology | ...: Array | published on: 27. 5. 2009

Spinal cord compression in spine tumours and injuries

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Orthotics page operated patients: 727 metastases 386 benign 98 malign 175 tumour-like affections 68 1984 – 2005 page mammar cancer 75 Grawitz. tumour 54 The most frequent metastases: Malignant tumours: myeloma 72 chordoma 17 chondrosarcoma 12 page anterior 168 posterior 350 combined – 1 team 164 - 2 teams 45 Surgeries page Frankel scale: A plegia, anesthesia B plegia, some sensory function C usefulles motor function D useful motor (gait) E normal page During surgery – heart failure, extensive blood loss Chylothorax Infection Exitus Complications page Quick progression of paresis Surgery to 24 hours after plegia onset Conclusion page SPINE INJURIES page AO classification of T+L injuries A anterior column injury (wedge, split, burst) B both columns – flexion distraction C both columns with rotation page Neural deficit in Th + L spine !!A type – mainly burst fractures !!B type - seldom !! ...

LF MU | discipline: Surgery, Traumatology and Orthopaedics | ...: Array | published on: 15. 4. 2009

Practical lessons 2

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... v=v9eNKf3MJAo&t=413s Seminal vesicles - lobulated glands, have strong muscular walls - location - lie against posterior surface of the urinary bladder lateral to the ampulla of ductus deferens, in a subperitoneal postion (the tips of seminal vesicles are covered by peritoneum) - function – contribute fluid to the ejaculate (produce about 70% of the ejaculate volume) produce a viscous and alkaline seminal fluid rich in fructose that nourishes the spermatozoa and protects them from the acidic enviroment of the female vagina - excretory duct – duct which joins ductus deferens to form ejaculatory duct (Ejaculatory ducts empty into the prostatic part of the urethra) ... Corpus spongiosum penis also contains wide vascular spaces, but the trabeculae of the smooth muscle are less prominent than in the corpora cavernosa. A filling of the cavernous spaces in the corpus spongiosum merely leads to “soft“ swelling, permitting sperm to be transported through the male urethra ...

UPJŠ LF v Košiciach | discipline: Anatomy | ...: Array | published on: 30. 6. 2018

Nádory štítné žlázy

Nádory štítné žlázy

Patologie a soudní lékařství ...

discipline: Surgery, Traumatology and Orthopaedics | keywords: Nádory štítné žlázy | published on: 9. 5. 2010

Nádory ledvin

Nádory ledvin

Patologie a soudní lékařství ...

discipline: Genetics | keywords: Nádory ledvin | published on: 24. 5. 2010

Karcinogeny

Karcinogeny

Patologie a soudní lékařství ...

discipline: Biology | keywords: Karcinogeny | published on: 22. 10. 2010

Chemická karcinogeneze

Chemická karcinogeneze

Lékařská chemie a biochemie ...

discipline: Genetics | keywords: Chemická karcinogeneze | published on: 2. 12. 2009

Fyzikální karcinogeneze

Fyzikální karcinogeneze

Lékařská chemie a biochemie ...

discipline: Genetics | keywords: Fyzikální karcinogeneze | published on: 2. 12. 2009

Henochova-Schönleinova purpura

Henochova-Schönleinova purpura

Patologie a soudní lékařství ...

discipline: Haematology | keywords: Henochova-Schönleinova purpura | published on: 3. 1. 2010

Imunokompetentní buňky

Imunokompetentní buňky

Fyziologie a patologická fyziologie ...

discipline: Physiology and Pathophysiology | keywords: Imunokompetentní buňky | published on: 11. 2. 2010

Practical lessons 1

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- Inguinal falx (conjoint tendon or conjunctival tendon) - Cremaster muscle – is a muscle that covers the testis and spermatic cord ... v=6lMKauO44rA Inguinal region: dissection of a female body (Akram Jaffar: ) https://www.youtube.com/watch? ...

UPJŠ LF v Košiciach | discipline: Anatomy | ...: Array | published on: 30. 6. 2018


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